Across Europe and Central Asia, the COVID-19 pandemic has resulted in a health and humanitarian crisis. It has also had multiple socio-economic impacts arising from loss of jobs and incomes, health and wellbeing, to disruptions in education and opportunity at all levels. The crisis has reinforced gender inequalities across age, ethnicity and social groups. Taken together, the pandemic’s impacts jeopardize the region’s progress on economic and social development goals, particularly decades of hard-won gains in gender equality, and place at risk the fundamental aim of the 2030 Agenda for Sustainable Development to leave no one behind.