The UN Decade on Ecosystem Restoration aims towards “living in harmony with nature” by 2050. In an anthropocentric and increasingly urbanized world, the inverse may be true as well: Harmony with nature is a necessary precondition for effective ecosystem restoration. We consider how megadiverse settings in developing economies present unique challenges and opportunities for making peace with nature. We show how towns and cities can provide a space for fostering harmony with nature and accelerating learning for conservation. Finally, we discuss opportunities for a collective, inclusive agenda for biodiverse cities.