In Asia and the Pacific, the impact of HIV is most evident at the household level, where once again, women are at the fore. Women, as caregivers, workers and surviving spouses, generally bear the brunt of the often devastating consequences of HIV. This practitioner’s guide builds on experience from the region in addressing issues of women and HIV. The guide offers evidence-based suggestions for policy and programmatic direction, and provides examples of promising practices from around the region to stimulate thinking and trigger effective responses.