The policy brief on the 2021 socio-economic impacts of COVID-19 in Cambodia was elaborated by the UN Development Programme (UNDP) and the Ministry of Economy and Finance (MEF), with support from the Australian government. The brief is based on an analysis using the integrated modelling framework used previously in the 2020 assessment. It consists of a computable general equilibrium (CGE) model using actual economic data to estimate the reaction of the economy to external factors, complemented by employment and poverty modules taken from a social accounting matrix (SAM) to capture relevant economic transactions and estimate the impacts of the pandemic on economic growth, poverty, and employment. Two recovery scenarios, namely, the baseline and moderate scenarios, are considered.