Work helps sustain livelihoods and largely determines the quality of life. Its changing nature is at the frontier of development. This report is the result of a broad horizon scanning by six UNDP Accelerator Labs across Europe and the Commonwealth of Independent States. They reveal 30 signals that shape the “where, who, how, and why” of the changing nature of work. From the impact of COVID-19 on the workforce to new work models and entrepreneurial ecosystems, the authors explore opportunities and threats, as well as solutions from local contexts that can be scaled up into positive answers to the challenges people around the world are facing.